GENETICS
1. Arrange events Of DNA finger printing in
sequence
A) fragmentation of DNA B) blotting
C) exposure on film to make a DNA
finger print
D) hybridization with probe E) separation by
electrophoresis
1) A
BCDE 2)
AEBDC
BCDE 2)
AEBDC
3) ABDEC 4)
BDCEA
BDEC 4)
BDCEA
2.
Sickle cell anaemia is
1)
Caused by substitution of valine by glutamic acid in the 
chain of haemoglobin
chain of haemoglobin
2) Characterised by the presence of
elongated sickle shaped RBC with a central nucleus
3) Caused by no
haemoglobin in most of the RBC
4) Caused by substitution of
glutamic acid by valine in the chain of
haemoglobin
chain of
haemoglobin
3. The following genetic disorder
causes building up of mucus in several internal organs
&
may lead to death at a very early age.
1)
Phenyl ketonuria 2) Haemophilia 3) Cystic fibrosis 4) DMD
4.
In human population these male individuals have male genitalia and internal
genital ducts; but their testes remain underdeveloped and feminine sexual
development is not completely suppressed
1)
Down’s syndrome 2)
Klinefelter syndrome
3) Turners syndrome 4)
Edward syndrome
5.
Study the following and choose the correct answer
SYNDROME ANEUPLOIDY CHARACTER/S
A) Cri-du-chat syndrome 8 P Monosomy Cat like cry
B) Edwards syndrome 18 Trisomy Cardiac abnormalities and kidney malfunctioning
C) Turner`s syndrome 23 monosomy Gonadial dysgenesis
D) Patau syndrome 13 Trisomy Leukemia cancer
Which of the above are correct?
1) A and B only 2) B and C only 3) B, C and D only 4) All
6. The number of genes located on
human chromosome-1 is
1)
2698 2) 2768 3) 2678 4) 2968
7.
Tandem repeats with clusters of 10 – 100 nucleotides are called
1)
Mini satellites 2) Nucleosomes 3) Solenoids 4) Micro satellites
8.
The fundamental technique involved in DNA
finger printing was pioneered and performed by
1) Jeffrys while
observing the gene related to dystrophin
2)
EM. Southern while observing the gene related to myoglobin
3)
EM. Southern while observing the gene related to dystrophin
4)
Jeffrys while observing the gene related to myoglobin
9. Study the following about
blood groups:
I. According to Weiner the number of genotypes that a child
can suffer from HDN is 16.
II. AB → A or B or O is compatible plasma transfusion.
III. Isoagglutinogens are of IgM type.
The correct ones of the
above are
1. Only I and II 2.
Only I and III 3. Only II and III 4. I, II and III
10. Unpaired allosome
determines the sex in females in
1. Grasshopper 2. Birds 3. Fumea 4. Drosophila
11. A man who
has haemophilia C and also suffering from tritanopia, married a normal woman
whose father suffered from both these traits. What is probability of occurrence
of both these traits in their daughters?
1. 25% 2.
50% 3. 75% 4. 0%
12. Match the following and choose the correct one
|
Genetic
disorder
|
Related to
|
|
A. Cri-du-chat-syndrome
|
1. Chromosome 11
|
|
B. Cystic fibrosis
|
2. Trisomy 18
|
|
C. Edwards syndrome
|
3. Chromosome 16
|
|
D. Beta thalassemia
|
4. Long arm of 7th
chromosome
|
|
|
5. 5P monosomy
|
1. A-5, B-4, C-2, D-3 2. A-4,
B-5, C-2, D-3
3. A-4, B-5, C-3, D-1 4. A-5,
B-4, C-2, D-1
13. Blood group
of wife is A+ and husband is B+ but their mothers are O-
; their first child is AB+ , what is the probability of their second
child having O+ blood group?
1. 1 out of 8 2. 1 out of 4 3. 3 out of 8 4. 3 out of 16
14. When male
Drosophila with bobbed bristles is crossed with homozygous wild female, the
males of the F2 progeny wild and bobbed bristles appear in the ratio
of
1. 1:1 2.
2 :1 3. 3 :1 4. 1 : 0
15. ASSERTION (A): In Drosophila melanogaster AAXO zygote
develops into male.
REASON (R): In Drosophila the male with above
compliment produces half of motile sperms
with AX condition
while the remaining half motile sperms are with AO condition.
1. Both ‘A’ and ‘R’ are true. ‘R’ is the correct explanation of ‘A’
2. Both ‘A’ and ‘R’ are true. But ‘R’ is the correct
explanation of ‘A’.
3. ‘A’ is true but ‘R’ is false 4. ‘A’ is false but ‘R’ is true
16. Common
feature between sex-limited and sex-influenced traits is
1. Both are due to linked genes 2. Expression is observed in both sexes
3. Both are due to autosomal genes
4. Expressed in homozygous condition in both sexes
17. Philadelphia chromosome is
1. Trisomy of 22nd chromosome 2. Abnormally long 9th
chromosome
3. Trisomy of 9th
chromosome 4.
Abnormally short 22nd chromosome
18. Wrong statement of the
following is
1. VNTRs are non-coding repetitive DNA. 2. SNPs help in tracing human history.
3.
The largest known human gene is located on the chromosome with highest number
of genes.
4.
Shotgun sequencing is used for sequencing of longer fragments of DNA.
19. The following is a typical example of pleiotropy
in human
1) Incontinentia pigmenti
2) Phenylketonuria
3)
Down’s syndrome 4)
Pattern baldness
20. Assertion (A): In follicular
hyperkeratosis, the homozygous affected female affects all her children
Reason (R) : Follicular hyperkeratosis is
X-linked dominant disease
1)
Both (A) and (R) are true and (R) is the correct explanation of (A)
2) Both (A) and (R) are true but (R)
is not the correct explanation of (A)
3) (A) is true but (R) is false 4) Both (A) and (R) are false
21. Haemolytic disease in foetus and new born
is due to
1) AO incompatibility 2)
Rh incompatibility
3)
OO incompatibility 4)
AB incompatibility
22. ‘BB’
bald and ‘O’ blood group woman married ‘Bb’ bald and ‘AB’ blood group
an and has given only male children. The probability of children is
1) all the children are bald with ‘A’ or ‘B’ blood groups
2)
all the children are non-bald with ‘A’ or ‘B’ blood groups
3)
all the children are bald with ‘AB’ or ‘O’ blood groups
4)
all the children are non-bald with ‘AB’ or ‘O’ blood groups
23. The female individuals share ¾ genes with
each other in
1)
haplo-diploidy in Apis 2) XX-XY method in Drosophila
3) ZO-ZZ method in Fumea 4)
XX-XO method in Periplaneta
24. Study the following pertaining to haemophilia
and choose the correct combinations
a. Haemophilia A is more common type
of haemophilia
b. Haemophilia-B people have lack of
functional clotting factor IX
c. Haemophilia-B is an autosomal
disorder
d. Haemophilia-A people lack the
functional clotting factor VII
1)
a and b 2) b and d 3) b and c 4) a and d
25. A recessive gene for bobbed condition is
present on Y-chromosome of male Drosophila.
When it is crossed with a heterozygous
wild female Drosophila, mention the
percentage of males with bobbed condition
1)
100% 2) 50% 3) 25% 4) 0%
26. Which of the following is an incorrect
statement?
1) SRY gene is a holandric gene 2) Development of beard
is Y-linked feature
3)
Formation of horn in Dorset sheep is sex influenced
4)
Phrynoderma is X-linked dominant
27. Study the following:
|
Disorder
|
Chromosome
|
Nature
|
|
I. Sickle cell anemia
|
11
|
Autosomal recessive
|
|
II. Hypertrichosis
|
23
|
X-linked dominant
|
|
III. Tritanopia
|
23
|
X-linked recessive
|
|
IV. Patau’s syndrome
|
13
|
Trisomy
|
The correct ones of the above are
1. II, III and IV only 2. III and IV only 3. I, II and III only 4.
I and IV only
28. ASSERTION (A): Mutation
of proto-oncogenes are dominant.
REASON ( R): Both copies
proto-oncogene gene in the homologous pair of chromosomes must undergo mutation
to allow cancer to develop.
1. Both ‘A’ and ‘R’ are true and ‘R’ is
correct explanation to ‘A’.
2.
Both ‘A’ and ‘R’ are true but ‘R’ is not correct explanation to ‘A’
3.
‘A’ is true but ‘R’ is false 4.
‘A’ is false but ‘R’ is true
29. Study the
following:
I. For X-linked genes males are hemizygous.
II. HDN develops in the foetus whose genotype is DD or Dd.
III. All holandric genes are transmitted by a male to his grandson
through his son.
The correct ones of the
above are
1. Only I and III 2.
Only I and II 3. Only II and
III 4. I, II and III
30. Which of
the following is heterogametic?
1. Male Fumea 2. Peacock 3. Female Fumea 4.
Female grasshopper
31. Skin colour in humans is a polygenic trait and
is controlled by three genes. Which of the following genotypes make same
genetic contribution to skin’s darkness?
1. aabbCC; aaBbCc; aaBBCc 2. AaBbcc;
aabbCC, aaBbCc
3. AaBbCc; AaBBCc; AAbbCc 4. AABbCc; AAbbCC;
aaBBcc
32. Morgan
carried out experiments in Drosophils to know how linkage affects inheritance.
What are the traits selected for these experiments
1) Body size and
wing colour 2)
Eye colour and wing size
3) Body bristles and wing colour 4) Body colour and wing size
33. The alleles of one of the following are not
pleiotropic. Identify
1)
Phenylketonuria 2) Cystic fibrosis 3) Sickle cell disease 4) Webbing of toes
34. Assertion (A) : Multiple alleles cannot be observed in
normal genotype but can be observed in population level.
Reason(R) : A gene may have more than
two alleles but only two of them occur in a diploid animal at a time
1) A and R are true and R is not the correct explanation of A.
2) A and R are true and R is
the correct explanation of A.
3) A is true, R is false. 4) A is false, R is true.
35. A haemotologist tested the blood samples of
a person with anti A serum, anti B serum and anti D serum (serum with anti D
antibodies) respectively, clumps are formed with all the antisera. The blood
group of the sample is
1) A+ve 2) B+ve 3) AB+ve 4) O+ve
36. Read the following statements
I)
Besides bone marrow the production of RBC occurs in spleen and Liver as well.
II) Circulating blood contains large
number of erythroblasts but not erythryocytes .
III) If the mother Rh+ve
and the foetus is Rh-ve IgG antibodies are administered
IV) Neonatal babies show symptoms like
Jaundice and Haemolytic anemia
Which of the above are related to HDNB
1) All 2) All except
III 3) I and II only 4) All except I
37. The skin colour of a Mulatto, a person of
black (AABBCC) and white (aabbcc) parentage is
1) Same as the
white parent 2)
Same as the black parent
3)
Intermediate of the parent 4)
Controlled by a pair of genes
38. Which of the following blood group does not
appear in the progeny, if one of the parent is with AB group
1) A 2) B 3) AB 4) O
39. Match the following
Blood transfusion Sevierity
of agglutination
A) A AB 1)
No agglutenition
AB 1)
No agglutenition
B) O O 2)
Light agglutenition
O 2)
Light agglutenition
C) O AB 3) Heavy agglutenition
AB 3) Heavy agglutenition
D) AB O
O
A B C D A B C D
1) 2 1 2 3 2) 2 1 3 2
3) 1 2 2 3 4) 1 2 3 2
40.
The pattern of inheritance of white eye colour in fruit fly is similar to that
of
1)
Hypertrichosis 2)
Bleeder’s diseases in humans
3) In continenutia pigmenti 4) Wild bristles in Drosophila
41. Assertion (A) : Human females have two
x-gene products where as males have only one
Reason ( R ) : Human females are
homozygous for x –linked genes
1) A and R are true and R is not the correct explanation of A.
2) A and R are true and R is the correct explanation of A.
3) A is true, R is false. 4) A is false, R is true.
42. A man with hemophilia has normal brother and
haemophilic sister. Their parents are
1)
Haemophilic father and carrier mother 2)
Haemophilic father and normal mother
3) Haemophilic mother
and haemophilic father 4)
Haemophilic mother normal father
43. One of the following trait is never seen in
human females
1) Pattern
baldness 2) Colour blindness 3) Hypertrichosis 4) Hyperkeratosis
44. Read the following
a) Bbxx b) Bbxy c)
BBxx d) bb xy
e) BBxy f) bbxx
It ‘B’ is for baldness and ‘b’ is for
normal hair which of the above genotypes are for normal hair
1) b, c and e 2) c, d and e 3) a, c and f 4) a, d and f
45. Study the following and choose the correct
combination
Method of sexdetermination Example Sex of the off spring depends on
A) zo – zz type Moths Fertilizing ovum
B) xx – xo type Grasshoppers Fertilizing ovum
C) xx – xy type Birds Fertilizing
sperm
D) zw – zz type Most manmals Fertilizing sperm
1)
A 2) B 3) C 4) D
46. Following are the statements related to
haplodiploidy in honeybees.
I)
Sex of the offspring is determined by the number of sets chromosomes
II) No chromosomal basis for the
fertility in females
III) Drones are haploid and fertile
IV) Drones have no father and no sons
but do have grand father and grandsons
In the above the correct are
1) All except I 2) All except II 3) All except Iii 4) All
are correct
47. Drum stick barr body is associated with
1) Fibroblasts of women 2) Neutrophils of women
3) Fibroblasts of men 4) Neutrophils of men
48. Sex chromosome component and haploid sets
of autosomes of a Drosophila are XXXY and AA respectively. It is (sexual phenotype)
1) Inter sex 2) Meta male 3) Meta female 4) Female
49. The above pedigree represent which trait ?
1) Autosomal
dominant 2) Autosomal recessive
3) X-linked dominant 4) X-linked recessive
50. Read the following.
I)
They are present in both males and females
II)
They can be expressed in both males and females(under normal conditions)
III) They can be inherited to both
males and females
Which of the above are true from
sex limited genes
1) I and II only 2) II and III only 3) I and III
only 4) I, II and III
51. Which of the following genetic disorder is
result of “Philadelphia translocation” in human genome.
1) Chronic myelogenous Leukemia 2)
Phenyl Ketonuria
3) Thalassemia 4) Bleeder’s disease
52. “Ishihara” colour test is most often used
to diagnose
1) Tritanopia 2) Deuternopia 3) Protanopia 4) Anaemia
53. In sickle cell anaemia, the point mutation
in the 
globin polypeptide chain of haemoglobin cause
the replacement of
globin polypeptide chain of haemoglobin cause
the replacement of
1) Valine by glutamic acid 2) Glutamic acid by valine
3) Phenyl alanine by Tyrosine 4) Tyrosine by phenyl alanine
54. Match the following.
List-I List-II
A)
Down syndrome 1) Trisomy 18
B)
Turner’s syndrome 2) Trisomy 13
C)
Patau syndrome 3) Monosomy 23
D)
Edward’s syndrome 4) Trisomy 21
A B C D A B C D
1) 4 3 1 2 2) 3 4 1 2
3) 4 3 2 1 4) 3 4 2 1
55. Read the following.
I)
Karyotype is 47, XXY
II) Gynacomastia III) Exhibit barr bodies
The above are related
1) Kline felter female 2) Turner female 3) Kline felter male 4)
Turner male
56. The basis of DNA finger printing is
1) Number of DNA particles 2) The variation
in the repeats of tandem arrays
3) Number of chromosomes 4) Only identical parts of DNA among
individuals
57. Assertion (A) : Restricted fragment
length polymers are genetic markers.
Reason (R) : VNTRs of two persons generally
show variations.
1) A and R are true and R is the correct
explanation of A.
2) A and R are true and R is not the correct
explanation of A.
3) A is true, R is false. 4) A is false, R is true.
58. Choose the correct from the following.
1) 123 genes – Y chromosome 2) Dystrophin – largest gene
3)
2,968 genes – 21st chromosome 4) Short gun sequence – DNA collection
59. During the course of breeding experiments,
horn formation in Dorset Horn sheep, it is observed that the heterozygous
genotype exhibit one phenotype in the male and contrasting one in the female.
This is an example of
1) Sex – linked in heritance 2) X- linked
– dominant inheritance
3) X – Y linked inheritance 4) Sex
– influenced inheritance
60. Three genes A, B, C control skin colour in
humans and from a trihybrid individual, how many types of gametes are expected?
1) Eight types 2) Six types 3) Four types 4) Three types
61. Study the following statements
A. Chronic myeloid leukemia people
shows reciprocal translocation of a piece of 9th chromosome with
piece of 22nd chromosome
B. Y- chromosome of man has least
number of genes
C. Pedigree analysis is not possible
with DNA finger printing
D. Down’s syndrome is with monosomy of
21st set of chromosome
Correct combination in the above is
1) A
– C –D 2) B – D 3) A – B 4) C – D
62. Follow the pedigree chart
The above inheritance indicates
1) Sex linked dominant trait 2) Autosomal
dominant trait
3) Sex linked recessive trait 4) Autosomal
recissive trait
63. The phenomenon of multiple effect of single
gene is called
1) Multiple allelism 2)
Polygenic inheritance
3)
Codominance 4)
Pleiotropy
64. When a heterozygous wild male Drosophila in test crossed with its
female parent, then in their progeny
1)
25% of male progeny show bobbed bristles 2) 50% of progeny show bobbed bristles
3)
50% of male progeny show bobbed bristles
4) 50% of female progeny show bobbed bristles
65. Genetic defect in which salt and water
movement across epithelial cell membranes is effected is
1)
thallessmia 2) sickle cell
anaemea 3) cystic fibrosis 4) alcaptoneurea
66. Largest known gene of humans is located on
the chromosome
1) 1st 2) y – chromosome 3) x- chromosome 4) 2nd
67. According to Fisher – Race system, Rh factor
involves
1)
Eight alleles at a single locus on homologous chromosome pair-I
2)
Two pairs of alleles on non-homologous chromosome pair-9
3)
Eight alleles at three loci on homologous chromosome pair-9
4)
Three pairs of alleles on homologous chromosome pair-1
68. A man, who is a son of bald mother and non
bald father, married a non bald homozygous woman. If they have two sons, what is the
probability of them being bald ?
1)
50% 2) 75% 3) 25% 4) 100%
69. Which of the following is true
regarding Barr bodies ?
1) Human
being affected by Klinefelter syndrome is without Barr bodies
2)
Barr and Bertram observed chromatin bodies in the interphase muscle cells of
female cats
3)
The Barr body in acidophils of woman is present as drumstick body
4)
Normal male human beings are without Barr bodies.
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